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The functional importance of this antagonism is demonstrated by the finding that the loss of self-renewal caused by CHAC2 knockdown is completely rescued by the additional knockdown of CHAC1

A comparison with chlorothiazide

Summary: GLP-1 receptor agonists can cause gas and bloating by slowing gastric emptying, which prolongs food transit through the digestive tract and increases bacterial fermentation

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Big picture (evidence base)